PI: 04/2021-03/2022 [TSSSU/HKBU/20/02/2] Optimization of phytonutrient-based remedial fluid for the management of hypertrophic and keloidal scars

PI: 04/2020-03/2021 [TSSSU/HKBU/20/02/1] Phytonutrient-based remedial nano mist for the removal of hypertrophic scars

PI: 01/2019-12/2020 [GRF12101718] Modulation of membrane type 1-matrix metalloproteinase by 3,5,4`-trihydroxybibenzyl, an aromatic dihydrostilbene, against perpetual pancreatic stellate cell activation in pancreatogenic diabetes

PI: 08/2017-12/2019 [HMRF14150471] Use of ephemeranthoquinone, a naturally occurring phenanthraquinone, in the treatment of pancreatic fibrosis in chronic pancreatitis

PI: 01/2017-12/2020 [NSFC81673476] Use of rhein/gemcitabine combinatory treatment in suppressing the progression and metastasis of pancreatic ductal adenocarcinoma

PI: 06/2016-05/2018 [HMRF13144281] Use of dihydro-resveratrol, a natural stilbenoid, in the treatment of acute pancreatitis and associated pulmonary injury

PI: 01/2015-12/2017 [NSFC81400666 young scientists project] Eruberin A suppresses the activation of pancreatic stellate cells and chronic pancreatitis via down-regulating sonic hedgehog signaling

Co-I: 12/2018-11/2020 [RC-IG-FNRA/17-18/12 HKBU] To synthesize a compound library based on diterpenes from Isodon plants for control of colorectal carcinoma progression and metastasis

Co-I: 09/2017-08/2019 [ITS/254/16] Synthesis of acetal analogs of 11-oxo-flexicaulin A for control of cancer progression and metastasis

Co-I: 09/2017-08/2019 [RC-IRMS/16-17/02 HKBU] Lanthanide folding single-chain polymeric nanoparticles-A smart drug delivery system for natural products

So DHF, Chan JCY, Tsui MG, Tsang PSW, Yao KM* (2020) Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism. Molecular and Cellular Endocrinology 518: 111026.

Sarwar MS, Xia YX, Liang ZM, Tsang SW, Zhang HJ* (2020) Mechanistic pathways and molecular targets of plant-derived anticancer ent-kaurane diterpenes. Biomolecules 10(1): pii: E144.

Xia Y, Lam CS, Li W, Sarwar MS, Liu K, Lee KM, Zhang HJ*, Tsang SW* (2019) Flexicaulin A, an ent-kaurane diterpenoid, activates p21 and inhibits the proliferation of colorectal carcinoma cells through a non-apoptotic mechanism. International Journal of Molecular Sciences 20(8): pii: E1917.

Xu XY^#, Tsang SW^#, Guan YF^#, Liu KL, Pan WH, Lam CS, Lee KM, Xia YX, Xie WJ, Wong WY, Lee MML, Tai WCS, Zhang HJ* (2019) In vitro and in vivo antitumor effects of plant-derived miliusanes and their induction of cellular senescence. Journal of Medicinal Chemistry 62(3): 1541-1561.

Wong HLX^#, Qin HY^#, Tsang SW, Zuo X, Che S, Chow CFW, Li X, Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian ZX* (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1): 1745.

Xia Y^#, Xiao HT^#, Liu KL, Zhang HJ*, Tsang SW* (2018) Resveratrol ameliorates the severity of fibrogenesis in mice with experimental chronic pancreatitis. Molecular Nutrition and Food Research 62(16): e1700561.

Zhu Y^#, Pan WH^#, Ku CF, Zhang HJ*, Tsang SW* (2018) Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. European Journal of Medicinal Chemistry 143: 1254-1260.

Sarwar MS, Zhang HJ, Tsang SW* (2018) Perspectives of plant natural products in inhibition of cancer invasion and metastasis by regulating multiple signaling pathways. Current Medicinal Chemistry 25(38): 5057-5087.

Guo L^#, Tsang SW^#, Zhang TX, Liu KL, Guan YF, Wang B, Sun HD, Zhang HJ*, Wong MS* (2017) Efficient semisynthesis of (−)-pseudoirroratin A from (−)-flexicaulin A and assessment of their antitumor activities. ACS Medicinal Chemistry Letters 8(3): 372-376.