The ATR signaling pathway, from basic research to targeted cancer therapy

20 July 2018 (Friday); 4:00 pm

by

Professor Lee Zou
Professor, Pathology, Harvard Medical School, USA
Associate Scientific Director, MGH Cancer Center, Massachusetts General Hospital, USA

in Rm. A2-08, 2/F, Mrs Chen Yang Foo Oi Telemedicine Centre
William MW Mong Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong

All are welcome

The ATR checkpoint pathway is a key regulator of DNA damage and replication stress responses in human cells. One of the Dr. Zou's main research interests is to understand how ATR is activated by DNA damage and genomic instability, and how ATR suppresses genomic instability in cancer cells. Recent studies by Dr. Zou's lab have discovered that ATR plays critical roles in response to the genomic instability induced by specific oncogenic events in cancer cells. These findings have provided new opportunities to target the ATR pathway in cancer therapy.