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Dr. Heylie Yin Ting WONG
 
Senior Lecturer
 
Office: Room 1903, 19/F, School of Medical and Health Sciences, Ma Kam Chan Memorial Building, 31 Wylie Road, Homantin, Kowloon, Hong Kong
Tel : (852) 3725 6216
Fax: (852) 2783 8635
 
Biography:
Dr. Heylie Wong, a Senior Lecturer at the School of Health and Medical Sciences, Tung Wah College. After completing her undergraduate studies at Southern Medical University and obtaining a Bachelor of Medicine in Medical Laboratory Science, she received training as a Hong Kong registered Part I medical laboratory technologist (Part I MLT) and China registered medical laboratory technologist. Dr. Wong completed her PhD in Biomedical Science at the City University of Hong Kong in 2022. Before joining Tung Wah College, Dr. Wong gained 4+ years of clinical frontline experience as a Part I Medical Technologist in the Department of Clinical Chemistry at Princess of Wales Hospital. Her expertise lies in Core Laboratory Diagnosis, LC-MS/MS Diagnosis, and Molecular Diagnosis. Dr. Wong has over 11 years of research experience in neuroscience. Her expertise includes studying neuron electrophysiology in learning and memory processes, such as long-term potentiation (LTP) and long-term depression (LTD). She also investigates the dynamic release of neurotransmitters before and after synaptic events, particularly substances like CCK and BDNF. Additionally, Dr. Wong specializes in advanced molecular testing, specifically Next-generation Sequencing (NGS), for the rapid diagnosis of Inborn Error Neuron-related diseases. She has published over 10 peer-reviewed research articles in renowned journals such as the Proceedings of the National Academy of Sciences (PNAS), Signal Transduction and Targeted Therapy (STTT), and the Journal of Neurochemistry (JNC). Dr. Wong holds a Chinese patent for a virus probe that monitors the secretion of CCK from presynaptic neurons to postsynaptic neurons, providing valuable insights into the role of CCK in neurons and its association with Alzheimer's disease. At present, Dr. Wong's research focuses on the rapid blood-based diagnosis and monitoring of Alzheimer's disease in humans.
 
Academic Qualifications
PhD (Biomedical Science), The City University of Hong Kong
BSc (Medical Laboratory Science), Southern Medical University, China
 
Professional Qualifications
Hong Kong Part I registered Medical Laboratory Technologist (Part I MLT), HK
China registered Clinical Medical Laboratory Technologist (MLT), China
Member of Hong Kong Society of Clinical Chemistry (HKSCC)
Member of Hong Kong Society of Medical Genetics (HKSMG)
Associate Member of the Australasian Association for Clinical Biochemistry and Laboratory Medicine (AACB)
 
Teaching Areas
Clinical Chemistry
Clinical Molecular Diagnostic
Biochemistry
Clinical Immunology
Human Physiology
 
Research Interests
Learning and Memory
Neurotransmitter release
Alzheimer’s Disease
Next-generation Sequencing
Clinical Hormone Detection
 
Publications (Selected)   
  1. Wong, Y.-T., Zheng, X., Lau, S.-H., Sun, K.-H., Chen, X., Li, H., Ng, S.-L., Jiang, H., Lau, G. C. Y., & He, J. (2024). Artificial fluorescent sensor reveals pre-synaptic NMDA receptors switch cholecystokinin release and LTP in the hippocampus. Journal of Neurochemistry, 00, 1–19. https://doi.org/10.1111/jnc.16128;
     
  2. 黃燕婷. Chinese Invention Patent (發明專利), “一种动态监测胆囊收缩素的生物荧光探针及其应用” 02 May 2024, (Accepted); Patent No. 202110516825.9. Principal Inventor.
     
  3. Li, Huangcan, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, and Ming-Liang He. "Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity." Signal Transduction and Targeted Therapy (STTT) 8, no. 1 (2023): 374.
     
  4. Sun, K. H $., Wong, Y. T $., Cheung, K. M., Yuen, C., Chan, Y. T., Lai, W. Y., ... & Tam, H. C. (2022). Update on Molecular Diagnosis in Extranodal NK/T-Cell Lymphoma and Its Role in the Era of Personalized Medicine. Diagnostics, 12(2), 409. *Co-first Author.
     
  5. Chen, X $., Li, X $., Wong, Y. T $., Zheng, X., Wang, H., Peng, Y., ... & He, J. (2019). Cholecystokinin    release triggered by NMDA receptors produces LTP and sound–sound associative memory. Proceedings of the National Academy of Sciences (PNAS), 116(13), 6397-6406. *Co-first Author.
     
  6. Zhang, H., Feng, L., Jiang, Y., Wong, Y. T., He, Y., Zheng, G., ... & Ho, D. (2017). A reaction-based near-infrared fluorescent sensor for Cu2+ detection in aqueous buffer and its application in living cells and tissues imaging. Biosensors and Bioelectronics, 94, 24-29.
     
  7. Zhang, H., Xiao, P., Wong, Y. T., Shen, W., Chhabra, M., Peltier, R., ... & Xie, Y. (2017). Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials, 140, 220-229.
     
  8. Wong, Y. T, et al. "TiO2-coated hollow glass microspheres with superhydrophobic and high IR-reflective properties synthesized by a soft-chemistry method." Journal of visualized experiments: JoVE 122 (2017). First Author.
     
  9. Wong, Y. T, et al. "A self-assembly and high-robustness super-hydrophobic coating based on waste marble powder." Materials Transactions (2016): M2016255. First Author.
     
  10. Chen, X., Liao, Z., Wong, Y. T., Guo, Y., & He, J. (2014). Time course of the dependence of associative memory retrieval on the entorhinal cortex. Neurobiology of learning and memory, 116, 155-161.
 
Funded Projects (Selected)      
    1. 06/2024 – 06/2026 (Principal Investigator)
Blood-based biomarkers for Alzheimer’s disease detection with LC/MS method and automatic Electrochemiluminescence measurement by Roche E411. Hong Kong Tung Wah College Research Grant. HK$130,000
 
 
 
 


Tung Wah College Logo
King’s Park Campus
Ma Kam Chan Memorial Building,
31 Wylie Road, Homantin, Hong Kong
Mongkok Campus
Cheung Kung Hai Memorial Building, 90A,
and Cheung Chin Lan Hong Building, 98,
Shantung Street, Mongkok, Hong Kong
Kwai Hing Campus
16/F, Tower 2,
Kowloon Commerce Centre,
51 Kwai Cheong Road,
Kwai Chung, Hong Kong
Telephone
(852) 3190 6678