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Research & ImpactNews & EventsDr. Marco TAM Shing YauAssistant Professor (Radiation Therapy)Office: Office: 2/F, School of Medical and Health Science, Nelson Court, 45 Waterloo Road, Mong Kok, Kowloon, Hong KongTel : (852) 34686624Fax: (852) 2783 8635Email : marcotam@twc.edu.hkBiographyDr. Tam is an Assistant Professor of the School of Medical and Health Sciences at Tung Wah College. Before joining Tung Wah College in 2023, he has been a Research Assistant Professor in Department of Health Technology and Informatics at the Hong Kong Polytechnic University. He has also been a Visiting Scholar in Department of Micro Engineering at the Kyoto University, Japan. He has experiences in supervising undergraduate and secondary school students for research mentoring programs and final year projects. Dr. Tam’s research interests include colorectal cancer, tumor microenvironment, personalized radiotherapy and radiation protection. His major research field focuses on the treatment and post-treatment care of colorectal cancer, including in vitro, in vivo and clinical levels. To date, he has published more than 25 peer-reviewed journal papers and conference abstracts with more than 10 publications acting as first/corresponding author. His publications have received more than 1300 citations with h-index of 11. He has also served as topical advisory panel, guest editor and reviewer of several peer-reviewed journals.Academic QualificationsPhD (2019), The Hong Kong Polytechnic UniversityBSc (Hon) in Radiography (Radiotherapy stream) (2014), The Hong Kong Polytechnic UniversityRegistered Radiographer Part II Category T, Hong Kong Radiographers BoardAuthor IdentificationsORCID ID: 0000-0002-5899-1041SCOPUS Author ID: 57193488434Honours and Awards (Selected)2023 Departmental Team Teaching Award (Co-PL), Dept of HTI, HKPolyU
Faculty Team Teaching Award Nominee (Co-PL), FHSS, HKPolyU2021 Fellowship Award, The Japan Society for the Promotion of Science (JSPS) Invitational Fellowship for Research in Japan (Short-term)
2019 Li Po Chun Charitable Trust Fund Scholarship
2014 First Class Honours in BSc (Hons) in Radiography (Radiation Therapy)
2014 Dean’s Honours List, Faculty of Health and Social Sciences, HKPolyU
2011-2014 The Hong Kong Polytechnic University Entry Scholarship (Academic)
Teaching AreasRadiobiology
Radiation Therapy
Honors Year ProjectResearch InterestsTumor microenvironment (Autophagy, Epithelial-mesenchymal transition, Hypoxia, Metastasis, Stemness maintenance)Colorectal cancerOrgan-on-a-chipPersonalized radiotherapyRadiation protectionFunded Projects (Selected)2021.1-2022.12 Investigation on the psychosocial needs of post-radiotherapy rectal cancer survivors and their direct caregivers in Hong Kong
Funded by Faculty Collaborative Research Scheme between Social Sciences and Health Sciences, FHSS, HKPolyU (HKD250,000, as Principal Investigator)2021.2-2022.6 Development of a new undergraduate subject in interdisciplinary cancer research
Funded by Strategic Plan Initiatives to Expand Research Elements in the Undergraduate Curriculum 2020-22, HKPolyU (HKD400,000, as Co-Project Leader)2021.4-2023.6 Deciphering of the role of low oxygen level and JNK pathway in colorectal cancer progression and treatment response
Funded by Start-up Fund for RAPs under the Strategic Hiring Scheme, HKPolyU (HKD250,000, as Principal Investigator)2021.6-2021.8 Visualization of tumor microenvironment and epithelial-mesenchymal transition by on-chip vessels (オンチップ血管網による腫瘍微小環境と上皮間葉転換の可視化)
Funded by Invitational Fellowships for Research in Japan, Japan Society for the Promotion of Science (JPY1,230,000, as Invited Fellow)2021.7-2023.6 Evaluation of Treatment induced-ROS in TRAIL-mediated Pathway and Apoptosis in Colorectal Cancer Cells
Funded by Undergraduate Research and Innovation Scheme (URIS), HKPolyU (HKD58,000, as Chief Supervisor)2021.12-2022.11 Investigation of the role of JNK in chemoresistance in colorectal cancer (探索JNK在结直肠癌细胞化疗耐药中的作用)
Funded by “百城百園”專項生命科學研究啟動基金, HKPolyU Shenzhen Research Institute (SZRI) (RMB225,000, as Principal Investigator)2022.5-2023.6 Using augmented reality (AR) for visualizing scatter radiation in clinical environments for the teaching and learning of radiation protection
Funded by Strategic Plan Initiatives to Enhance the Student Learning Experience through the Use of Interactive Pedagogies 2021-22, HKPolyU (HKD200,000, as Project Leader)Publications (Selected)- Tam SY (First and Corresponding Author), Fung YY, Lau SY, Lam WN, Wong ETH. Scatter Radiation Distribution to Radiographers, Nearby Patients and Caretakers during Portable and Pediatric Radiography Examinations. Bioengineering 2023;10:7:779. Doi: 10.3390/bioengineering10070779 (IF 2022: 4.6)
- Tam SY (First and Corresponding Author), Islam Khan MZ, Chen JY, Yip JHY, Yan HY, Tam TY, Law HKW. Proteomic profiling of chemotherapy responses in FOLFOX-resistant colorectal cancer cells. Int J Mol Sci 2023;24:12:9899. Doi: 10.3390/ijms24129899 (IF 2022: 5.6)
- Tam SY (First and Corresponding Author), Islam Khan MZ, Yip JHY, Yan HY, Tam TY, Law HKW. Proteomic profiling of FOLFOX-resistant colorectal cancer cells. J Clin Oncol 2023;41:16_suppl, e15588. Doi: 10.1200/JCO.2023.41.16_suppl.e15588 (IF 2022: 45.3)
- Tam SY (First Author), Tam VCW, Law HKW, Khaw ML, Lee SWY. Rationale for Mass Masking in Controlling the COVID-19 Pandemic. Front Public Health 2021;9:665708. Doi: 10.3389/fpubh.2021.665708 (IF 2022: 5.2)
- Tam SY (First and Corresponding Author), Law HKW. JNK in Tumor Microenvironment: Present Findings and Challenges in Clinical Translation. Cancers 2021;13:9:2196. Doi: 10.3390/cancers13092196 (IF 2022: 5.2)
- Klionsky DJ, …, Tam SY et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021;1-382. Doi: 10.1080/15548627.2020.1797280 (IF 2022: 13.3)
- Tam SY (First Author), Tam VCW, Ramkumar S, Khaw ML, Law HKW, Lee SWY. Review on the cellular mechanisms of low-level laser therapy use in oncology. Front Oncol 2020;10:1255. Doi: 10.3389/fonc.2020.01255 (IF 2022: 4.7)
- Tam SY (First Author), Wu VWC, Law HKW. Hypoxia-induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond. Front Oncol 2020;10:486. Doi: 10.3389/fonc.2020.00486 (IF 2022: 4.7)
- Tam SY (First Author), Wu VWC, Law HKW. JNK Pathway Mediates Low Oxygen Level Induced Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer Cells. Cancers 2020;12:1:224. Doi: 10.3390/cancers12010224 (IF 2022: 5.2)
- Tam SY (First Author), Wu VWC, Law HKW. Dynamics of oxygen level-driven regulators in modulating autophagy in colorectal cancer cells. Biochem Biophys Res Commun 2019;517:2:193-200. Doi: 10.1016/j.bbrc.2019.07.043 (IF 2022: 3.1)
- Tam SY (First Author), Wu VWC. A review on the special radiotherapy techniques of colorectal cancer. Front Oncol 2019;9:208. Doi: 10.3389/fonc.2019.00208 (IF 2022: 4.7)
- Tam SY (First Author), Wu VWC, Law HKW. Influence of Autophagy on the Efficacy of Radiotherapy. Radiat Oncol 2017;12:57. Doi: 10.1186/s13014-017-0795-y (IF 2022: 3.6)
Community/ Professional Contributions (Selected)2023-present Executive Committee Member, The Radiography Alumni Association of HKPolyU 2023-present Topical Advisory Panel and Guest Editor for Gastroenterology Insights (MDPI) 2021-present Reviewer board member of Frontiers in Bioscience-Landmark (IMR Press, IF: 3.1), Frontiers in Oncology (Frontiers, IF: 4.7) 2020-present Member of Hong Kong Association of Radiation Therapists 2020-present Member of The Hong Kong Radiographers’ Association 2020-present Invited Reviewer for Bioengineered, Biology, Cancers, International Journal of Molecular Sciences, International Journal of Radiation Oncology, Journal of Cellular and Molecular Medicine and Journal of Selected Topics in Quantum Electronics 2020-2023 Departmental Health and Safety Officer, Dept of HTI, HKPolyU 2020-2023 Radiation Protection Officer, Dept of HTI, HKPolyU 2023-present Executive Committee Member, The Radiography Alumni Association of HKPolyU 2023-present Topical Advisory Panel and Guest Editor for Gastroenterology Insights (MDPI) 2021-present Reviewer board member of Frontiers in Bioscience-Landmark (IMR Press, IF: 3.1), Frontiers in Oncology (Frontiers, IF: 4.7) 2020-present Member of Hong Kong Association of Radiation Therapists 2020-present Member of The Hong Kong Radiographers’ Association 2020-present Invited Reviewer for Bioengineered, Biology, Cancers, International Journal of Molecular Sciences, International Journal of Radiation Oncology, Journal of Cellular and Molecular Medicine and Journal of Selected Topics in Quantum Electronics 2020-2023 Departmental Health and Safety Officer, Dept of HTI, HKPolyU 2020-2023 Radiation Protection Officer, Dept of HTI, HKPolyU
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