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Dr. Phyllis Siu Wai TSANG
Assistant Professor
Office: Room 1001A, 10/F, School of Medical and Health Sciences, Ma Kam Chan Memorial Building, 31 Wylie Road, Homantin, Kowloon, Hong Kong
Tel : (852) 3190 6713
Fax: (852) 2783 8635
Before joining TWC in 2022, Dr. Tsang served as a part-time lecturer (2019-2021) in the Division of Nursing, School of Continual Education, and a research assistant professor (2015-2020) in the School of Chinese Medicine at Hong Kong Baptist University. With a passion to translate the results of basic research studies into remedial and commercial products, as a co-founder, she established a biotech company in 2019 that was support by the Technology Start-up Support Scheme for Universities (TSSSU) and Incubation Programme of Hong Kong Science and Technology Parks Corporation (HKSTP).
Author Identifications
ORCID: 0000-0001-6099-6696
ResearcherID: O-2748-2013
PhD (Biochemistry), The University of Hong Kong, HKSAR, China
MPhil (Physiology), The Chinese University of Hong Kong, HKSAR, China
BSc (Biotechnology, minor in Microbiology), The Pennsylvania State University, PA, USA
Honours and Awards
NIDDK fellowship service awards (2008-2009 and 2009-2010), National Institutes of Health, USA
Bronze Medal of the 1st Asia Exhibition of Inventions of Hong Kong (2018)
Second Prize in The Innovation Nanshan “Entrepreneurs Star Contest” (2019)
Teaching Areas
Biochemistry and Molecular Biology
Research Interests
Pathophysiology and molecular mechanisms of acute and chronic pancreatitis, diabetes, fibrosis, hypertrophic scars and different types of cancer
Drug discovery of small molecules and herbal compounds
Funded Projects (Selected)

PI: 04/2021-03/2022 [TSSSU/HKBU/20/02/2] Optimization of phytonutrient-based remedial fluid for the management of hypertrophic and keloidal scars

PI: 04/2020-03/2021 [TSSSU/HKBU/20/02/1] Phytonutrient-based remedial nano mist for the removal of hypertrophic scars

PI: 01/2019-12/2020 [GRF12101718] Modulation of membrane type 1-matrix metalloproteinase by 3,5,4`-trihydroxybibenzyl, an aromatic dihydrostilbene, against perpetual pancreatic stellate cell activation in pancreatogenic diabetes

PI: 08/2017-12/2019 [HMRF14150471] Use of ephemeranthoquinone, a naturally occurring phenanthraquinone, in the treatment of pancreatic fibrosis in chronic pancreatitis

PI: 01/2017-12/2020 [NSFC81673476] Use of rhein/gemcitabine combinatory treatment in suppressing the progression and metastasis of pancreatic ductal adenocarcinoma

PI: 06/2016-05/2018 [HMRF13144281] Use of dihydro-resveratrol, a natural stilbenoid, in the treatment of acute pancreatitis and associated pulmonary injury

PI: 01/2015-12/2017 [NSFC81400666 young scientists project] Eruberin A suppresses the activation of pancreatic stellate cells and chronic pancreatitis via down-regulating sonic hedgehog signaling

Co-I: 12/2018-11/2020 [RC-IG-FNRA/17-18/12 HKBU] To synthesize a compound library based on diterpenes from Isodon plants for control of colorectal carcinoma progression and metastasis

Co-I: 09/2017-08/2019 [ITS/254/16] Synthesis of acetal analogs of 11-oxo-flexicaulin A for control of cancer progression and metastasis

Co-I: 09/2017-08/2019 [RC-IRMS/16-17/02 HKBU] Lanthanide folding single-chain polymeric nanoparticles-A smart drug delivery system for natural products

Publications (Selected from recent 5 years)

So DHF, Chan JCY, Tsui MG, Tsang PSW, Yao KM* (2020) Secreted PDZD2 exerts an insulinotropic effect on INS-1E cells by a PKA-dependent mechanism. Molecular and Cellular Endocrinology 518: 111026.

Sarwar MS, Xia YX, Liang ZM, Tsang SW, Zhang HJ* (2020) Mechanistic pathways and molecular targets of plant-derived anticancer ent-kaurane diterpenes. Biomolecules 10(1): pii: E144.

Xia Y, Lam CS, Li W, Sarwar MS, Liu K, Lee KM, Zhang HJ*, Tsang SW* (2019) Flexicaulin A, an ent-kaurane diterpenoid, activates p21 and inhibits the proliferation of colorectal carcinoma cells through a non-apoptotic mechanism. International Journal of Molecular Sciences 20(8): pii: E1917.

Xu XY#, Tsang SW#, Guan YF#, Liu KL, Pan WH, Lam CS, Lee KM, Xia YX, Xie WJ, Wong WY, Lee MML, Tai WCS, Zhang HJ* (2019) In vitro and in vivo antitumor effects of plant-derived miliusanes and their induction of cellular senescence. Journal of Medicinal Chemistry 62(3): 1541-1561.

Wong HLX#, Qin HY#, Tsang SW, Zuo X, Che S, Chow CFW, Li X, Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian ZX* (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1): 1745.

Xia Y#, Xiao HT#, Liu KL, Zhang HJ*, Tsang SW* (2018) Resveratrol ameliorates the severity of fibrogenesis in mice with experimental chronic pancreatitis. Molecular Nutrition and Food Research 62(16): e1700561.

Zhu Y#, Pan WH#, Ku CF, Zhang HJ*, Tsang SW* (2018) Design, synthesis and evaluation of novel dihydrostilbene derivatives as potential anti-melanogenic skin-protecting agents. European Journal of Medicinal Chemistry 143: 1254-1260.

Sarwar MS, Zhang HJ, Tsang SW* (2018) Perspectives of plant natural products in inhibition of cancer invasion and metastasis by regulating multiple signaling pathways. Current Medicinal Chemistry 25(38): 5057-5087.

Guo L#, Tsang SW#, Zhang TX, Liu KL, Guan YF, Wang B, Sun HD, Zhang HJ*, Wong MS* (2017) Efficient semisynthesis of (−)-pseudoirroratin A from (−)-flexicaulin A and assessment of their antitumor activities. ACS Medicinal Chemistry Letters 8(3): 372-376.

Patents (Selected from recent 5 years)
US10493056B2 (12/2019) Method of use of diterpenoid derivatives as anticancer agents – CIP
US10351500B2 (07/2019) Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants as antimicrobial agents
US10188590B2 (01/2019) Skin-protection composition containing Dendrobium-based ingredients – CIP
US10017442B2 (07/2018) Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatment of tumorous pathologies
US9956152B2 (05/2018) Skin-protection composition containing Dendrobium-based ingredients
HK1206618 (05/2018) 一种用于治疗炎症性肠病的中草药配方及其制备方法
CN201410210304.0 (04/2018) 黄烷醇糖苷在抑制星状细胞活化上的应用
US9877931B2 (01/2018) Method of using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions – CIP
Community/ Professional Contributions (Selected)
Journal reviewer for Phytotherapy Research, European Journal of Medicinal Chemistry and Journal of Cellular Biochemistry

Tung Wah College Logo
King’s Park Campus
Ma Kam Chan Memorial Building,
31 Wylie Road, Homantin, Hong Kong
Mongkok Campus
Cheung Kung Hai Memorial Building, 90A,
and Cheung Chin Lan Hong Building, 98,
Shantung Street, Mongkok, Hong Kong
Kwai Hing Campus
16/F, Tower 2,
Kowloon Commerce Centre,
51 Kwai Cheong Road,
Kwai Chung, Hong Kong
(852) 3190 6678