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Dr. Sarwat FATIMA
Lecturer (講師)
Office: 16/F, School of Nursing, Ma Kam Chan Memorial Building, 31 Wylie Road, Homantin, Kowloon, Hong Kong
Telephone: (852) 3725 6225
Dr. Sarwat Fatima joined the School of Nursing in 2022 as a lecturer.  She completed her BSc (Hons) and MPhil studies from the Hong Kong Polytechnic University. Her MPhil research was on identification of novel oncogenes in esophageal squamous cell carcinoma (ESCC). She obtained her PhD from the University of Hong Kong and pursued part of her PhD studies at the National University of Singapore (NUS). Following her PhD, Dr. Fatima pursued 6 years of post-doctoral research at the Hong Kong Baptist University. Both her PhD and post-doctoral research studies were focused on identifying cellular and molecular mechanisms in hepatocellular (HCC) and colorectal cancer (CRC) progression. Dr. Fatima has authored book chapters on molecular biomarkers for cancers as well as made contributions to various publications in peer-reviewed journals. Following her post-doctoral studies, she led a research and development team at a private company investigating liquid biopsy.  Recently she completed an online course in bioethics from Harvard University. Currently her research interests lie in the role of machine learning in cancer diagnosis and/or prognosis.
Academic and Professional Qualifications
Bsc (Hons), MPhil, PhD

Author Identifications
ORCID ID: 0000-0001-7117-126X

Bioethics: The Law, Medicine, and Ethics of Reproductive Technologies and Genetics (online course). Harvard University, USA
PhD, Faculty of Medicine, The University of Hong Kong
MPhil, Faculty of Science, The Hong Kong Polytechnic University
BSc (Hons) Applied Biology with Biotechnology, Faculty of Science, The Hong Kong Polytechnic University
Teaching Areas
Human anatomy and physiology
Advanced pathophysiology
Research Interests
Cellular and molecular mechanisms of cancers
Application of machine learning in cancer diagnosis and/or prognosis
Peer-reviewed journal articles
Hu X*, Fatima S*, Huang T, Chen M, Gong RH, Ho AHM, Wong HLX, Yu R, Song L, Kwan HY, Bian Z (2021). Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level.  Cell Death and Dis 12(11):1053. * Equal contribution
Hu XJ*, Fatima S*, Chen MT, Huang CH, Ho AHM, Gong RH, Su T, Wong HLX, Bian ZX, Kwan HY (2021). High fat diet increases colorectal cancer growth: Role of toll-like receptor 4. Cell Death Dis 12(8):791. * Equal contribution
Fatima S, Hu X, Gong RH, Huang C, Chen M, Wong HLX, Bian Z, Kwan HY (2019). Palmitic Acid Is an Intracellular Signaling Molecule Involved in Disease Development. Cell Mol Life Sci,76(13):2547-2557. 
Fatima S, Hu X, Huang C, Zhang W, Cai J, Huang M, Gong RH, Chen M, Ho AHM, Su T, Wong HLX, Bian Z, Kwan HY (2019). High-fat Diet Feeding and Palmitic Acid Increase CRC Growth in β2AR-dependent Manner. Cell Death Dis,10(10):711.
Kwan HY, Liu B, Huang CH, Fatima S, Su T, Zhao XS, Ho AHM, Han QB, Hu X, Gong RH, Chen MT, Wong HLX, Bian ZX. Signal transducer and activator of transcription-3 (STAT-3) drives the high fat diet-associated prostate cancer growth (2019). Cell Death Dis 10(9):637. 
Vellaisamy K, Li G, Ko CN, Zhong HJ, Fatima S, Kwan HY, Wong CY, Kwong WJ, Tan W, Leung CH, Ma DL (2017). Cell imaging of dopamine receptor using agonist labeling iridium(iii) complex. Chem Sci 9(5):1119-1125. 
Fatima S, Xiaoki Shi, Zesi Lin, Guo-qing Chen, Xiao-hua Pan, Justin Che–Yuen Wu, John W. Ho, Nikki P. Lee, Hengjun Gao, Zhao Xiang Bian (2016). 5-Hydroxytryptamine promotes hepatocellular carcinoma by influencing β-catenin.  Molecular Oncology, 10(2):195-212. 
Li YH, Xiao HT, Hu DD, Fatima S, Lin CY, Mu HX, Lee NP, Bian ZX (2016). Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 Responses. Pharmacol Res, 110:227-39. 
Guo-qing Chen, Cheng-fang Tang, Xiao-ke Shi, Cheng-yuan Lin, Sarwat Fatima, Xiaohua Pan, Da-jian Yang, Ge Zhang, Ai-ping Lu, Shu-hai Lin, Zhao-xiang Bian (2015).  Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling. Oncotarget, 6(27):24148-62. 
Fatima S, Luk JM and Lee NP (2014).  Dysregulated expression of dickkopfs (DKKs) for potential detection of hepatocellular carcinoma.  Expert Rev of Mol Diagn, 14(5):535-548. 
Shek FH, Fatima S, Lee NP. Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma (2012).  Int J Hepatol, 2012:760928. 
Fatima S, Lee NP, Tsang FH, Kolligs FT, Ng IOL, Poon RTP, Fan ST, Luk JM (2012).  Dickkopf 4 (DKK4) acts on Wnt/β-catenin pathway via influencing β-catenin in hepatocellular carcinoma.   Oncogene, 20;31(38):4233-4244. 
Fatima S, Lee NP, Luk JM (2011).  Dickkopfs (DKKs) and Wnt/β-catenin signalling in liver cancer.  World J of Clin Oncol, 2(8):311-325. 
Fatima S, Chui CH, Tang WK, Hui KS, Au HW, Li WY, Wong MM, Cheung F, Tsao SW, Wong J, Law S, Srivastava G, Ho KP, Chan ASC, and Tang JCO (2006).  Transforming capacity of two novel genes JS-1 and JS-2 located in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma.  Int J of Mol Med, 17(1):159-170. 
Book chapters
Fatima S, Nikki P. Lee, Hiu Yee Kwan and Zhao-Xiang Bian. Emerging targeted therapies for treatment of hepatocellular carcinoma.  In: Hepatocellular Carcinoma - Advances in Diagnosis and Treatment, 2017.
Fatima S, Nikki P. Lee and Bian Zhao-Xiang.  Current and emerging cancer therapies for treatment of hepatocellular carcinoma. In: Frontiers in Biomedical Science, 2015.
Kenneth K. Lai, Kin-Tak Chan, Fatima S, Nikki P. Lee, Simon Law.  Circulating biomarkers for esophageal squamous cell carcinoma.  In: New Advances on Disease Biomarkers and Molecular Targets in Cancer and Biomedicine. Springer Publishers, 2013.
Felix H. Shek, Tracy C.W. Lai, Fatima S, Nikki P. Lee.  Oncofetal molecules as biomarkers and drug targets for hepatic cancer.  In: New Advances on Disease Biomarkers and Molecular Targets in Cancer and Biomedicine. Springer Publishers, 2013.  
Luk JM, Fatima S, Lee NP, Fan ST. Liver cancer biomarkers.  In: Dan Hellberg (Ed.),Textbook - Histological and serological tumor markers and their clinical usefulness in cancer. Nova Publishers Inc, New York, USA, 2008.
Community/ Professional Contributions (Selected)
Associate Member, the American Association for Cancer Research

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King’s Park Campus
Ma Kam Chan Memorial Building,
31 Wylie Road, Homantin, Hong Kong
Mongkok Campus
Cheung Kung Hai Memorial Building, 90A,
and Cheung Chin Lan Hong Building, 98,
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Kwai Hing Campus
16/F, Tower 2,
Kowloon Commerce Centre,
51 Kwai Cheong Road,
Kwai Chung, Hong Kong
(852) 3190 6678