Tung Wah College - School of Nursing - Our Staff - Academic Staff

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About TWC

Admission

Programmes

Bachelor’s Degree Programmes

Bachelor of Education (Honours) in Early Childhood Education

Bachelor of Health Information and Services Management (Honours)

Bachelor of Health Science (Honours) in Nursing

Bachelor of Management (Honours) in Social and Business Sustainability

Bachelor of Science (Honours) in Applied Gerontology

Bachelor of Science (Honours) in Biomedical Science

Bachelor of Science (Honours) in Forensic Biomedical Science

Bachelor of Science (Honours) in Medical Imaging

Bachelor of Science (Honours) in Medical Laboratory Science

Bachelor of Science (Honours) in Occupational Therapy

Mainland Admission

内地生入学计划

Academic Units

Administration Units

Teaching & Learning

Research & Impact

Translational Research Centre for Digital Mental Health (TRC-DMH)

News & Events

School of Nursing

Dr. Sam Kit San YUEN (阮傑燊博士)

Assistant Professor (助理教授)

Office: 16/F, School of Nursing, Ma Kam Chan Memorial Building, 31 Wylie Road, Kowloon, Hong Kong

Telephone: (852) 3468 6641

Email: [email protected]

Biography

Sam received his bachelor’s degree in Applied Biology with Biotechnology from the Hong Kong Polytechnic University and continued his PhD studies in the field of molecular virology at the University of Hong Kong. His research focuses on the Epstein-Barr virus in nasopharyngeal carcinoma, virus and innate immunity, and CRISPR/Cas-mediated genome editing. Sam joined Tung Wah College as a senior lecturer in the School of Medical and Health Sciences in 2020 and was promoted to assistant professor in the School of Nursing in 2022. He is responsible for teaching foundation science subjects for nursing students.

Academic and Professional Qualifications

BSc (Hons), PhD

Author Identifications

ORCID ID: 0000-0002-1394-7709

SCOPUS Author ID: 55588721400

Education

Doctor of Philosophy, Department of Biochemistry, The University of Hong Kong (Hong Kong)

Bachelor of Science (Hons) in Applied Biology with Biotechnology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University (Hong Kong)

Honours and Awards

Postdoctoral Fellow Travel Award, American Society for Virology (2015)

Outstanding oral presentation in 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium (2013)

Ming K. Jeang Scholarship Award, Society of Chinese Bioscientists in America (2011)

Outstanding poster presentation in 2011 Hong Kong Inter-University Biochemistry Postgraduate Symposium (2011)

HKU University Postgraduate Fellowship, The University of Hong Kong (2010-2011)

San Miguel Beer Scholarship, The Hong Kong Polytechnic University (2009-2010)

CMA & Donors Scholarship, The Hong Kong Polytechnic University (2008-2009)

Huang Yi-Jung Scholarship for Applied Science, The Hong Kong Polytechnic University (2007-2008)

Dean’s Honours List, Faculty of Applied Science and Textiles, The Hong Kong Polytechnic University (2007/2008, 2008/2009, 2009/2010)

HKSAR Government Scholarship, HKSAR (2007/2008, 2008/2009)

Post-entry Scholarship for Current Students on UGC-funded Undergraduate Programmes, The Hong Kong Polytechnic University (2007/2008, 2008/2009)

Teaching Areas

Microbiology

Pathophysiology

Anatomy and Physiology

Research Interests

Epstein-Barr virus in nasopharyngeal carcinoma

Virus and innate immunity

CRISPR/Cas-mediated genome editing

Funded Projects (Selected)

Validation of ATP-based and β-galactosidase-based hygiene evaluation methods on different antimicrobial coating or embedded materials. Funded by College Research Grant (CRG), Tung Wah College. (Principial investigator, Project No.: CRG2022/05) (Hong Kong) (2023-2024) – HK$130,000.

Cure of Epstein-Barr virus in nasopharyngeal carcinoma cells through combinational CRISPR/Cas9 and CRISPR/Cas13 targeting. Funded by Faculty Development Scheme (FDS), University Grant Committee, HKSAR Government (Principial investigator, Project No.: UGC/FDS17/M07/22) (Hong Kong) (2023-2024) – HK$826,457.

Mechanism of inflammasome activation by SARS-CoV-2. Funded by Collaborative Research Fund (CRF), University Grant Committee, HKSAR Government (Co-principal investigator, Project No.: C7142-20G) (Hong Kong) (2021-2024) – HK$8,431,247.

Roles of caspase 3 activation in lytic replication of Epstein-Barr virus in nasopharyngeal epithelial cells. Funded by the Health and Medical Research Fund (HMRF), Food and Health Bureau, HKSAR Government (Co-investigator, Project No.: 18170942) (Hong Kong) (2019-2022) – HK$1,500,000.

Suppression of type I and type II interferon production and signaling by Epstein-Barr virus BGLF2 protein. Funded by the Health and Medical Research Fund (HMRF), Food and Health Bureau, HKSAR Government (Co-investigator, Project No.: 17160822) (Hong Kong) (2018-2021) – HK$1,200,000.

Publications (Selected)

Lui, W. Y., Ong, C. P., Cheung, P. H. H., Ye, Z. W., Chan, C. P., To, K. K. W., Yuen, K. S., & Jin, D. -Y. (2024). Nsp1 facilitates SARS-CoV-2 replication through calcineurin-NFAT signaling. mBio, 15(4), Article e0039224. https://doi.org/10.1128/mbio.00392-24. [IF: 5.1, 2023]

Lui, W. Y., Bharti, A., Wong, N. M., Jangra, S., Botelho, M. G., Yuen, K. S.*, & Jin, D. Y.* (2023). Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1. PLoS pathogens, 19(2), e1011186. https://doi.org/10.1371/journal.ppat.1011186 [IF: 7.464, 2022] *Co-corresponding authorship

Yuen, K. S., Ye, Z. W., Fung, S. Y., Cheung, P. H., Chan, C. P., & Jin, D. Y. (2021). SARS-CoV-2 and COVID-19: revisiting the most important research questions. Cell & bioscience, 11(1), 215. https://doi.org/10.1186/s13578-021-00730-1 [IF: 8.389, 2022]

Jangra, S., Bharti, A., Lui, W. Y., Chaudhary, V., Botelho, M. G.*, Yuen, K. S.*, & Jin, D. Y*. (2021). Suppression of JAK-STAT Signaling by Epstein-Barr Virus Tegument Protein BGLF2 through Recruitment of SHP1 Phosphatase and Promotion of STAT2 Degradation. Journal of virology, 95(20), e0102721. https://doi.org/10.1128/JVI.01027-21 [IF: 6.208, 2021] *Co-corresponding authorship

Yuen, K. S., Ye, Z. W., Fung, S. Y., Chan, C. P., & Jin, D. Y. (2020). SARS-CoV-2 and COVID-19: The most important research questions. Cell & bioscience, 10, 40. https://doi.org/10.1186/s13578-020-00404-4 [IF: 5.969, 2020]

Siu, K. L., Yuen, K. S., Castaño-Rodriguez, C., Ye, Z. W., Yeung, M. L., Fung, S. Y., Yuan, S., Chan, C. P., Yuen, K. Y., Enjuanes, L., & Jin, D. Y. (2019). Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 33(8), 8865–8877. https://doi.org/10.1096/fj.201802418R [IF: 4.028, 2019]

Jangra, S., Yuen, K. S., Botelho, M. G., & Jin, D. Y. (2019). Epstein-Barr Virus and Innate Immunity: Friends or Foes?. Microorganisms, 7(6), 183. https://doi.org/10.3390/microorganisms7060183 [IF: 3.864, 2020]

Yuen, K. S., Wang, Z. M., Wong, N. M., Zhang, Z. Q., Cheng, T. F., Lui, W. Y., Chan, C. P., & Jin, D. Y. (2018). Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9. Virus research, 244, 296–303. https://doi.org/10.1016/j.virusres.2017.04.019 [IF: 2.717, 2018]

Chaudhary, V., Yuen, K. S., Chan, J. F., Chan, C. P., Wang, P. H., Cai, J. P., Zhang, S., Liang, M., Kok, K. H., Chan, C. P., Yuen, K. Y., & Jin, D. Y. (2017). Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein. Journal of virology, 91(14), e00163-17. https://doi.org/10.1128/JVI.00163-17 [IF: 4.403, 2017]

Yuen, K. S., Chan, C. P., Kok, K. H., & Jin, D. Y. (2017). Mutagenesis and Genome Engineering of Epstein-Barr Virus in Cultured Human Cells by CRISPR/Cas9. Methods in molecular biology (Clifton, N.J.), 1498, 23–31. https://doi.org/10.1007/978-1-4939-6472-7_2 [IF: 0.946, 2017]

Chaudhary, V., Zhang, S., Yuen, K. S., Li, C., Lui, P. Y., Fung, S. Y., Wang, P. H., Chan, C. P., Li, D., Kok, K. H., Liang, M., & Jin, D. Y. (2015). Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation. The Journal of general virology, 96(11), 3204–3211. https://doi.org/10.1099/jgv.0.000280 [IF: 3.486, 2015]

Yuen, K. S., Chan, C. P., Wong, N. M., Ho, C. H., Ho, T. H., Lei, T., Deng, W., Tsao, S. W., Chen, H., Kok, K. H., & Jin, D. Y. (2015). CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells. The Journal of general virology, 96(Pt 3), 626–636. https://doi.org/10.1099/jgv.0.000012 [IF: 3.486, 2015]

Lei, T., Yuen, K. S., Tsao, S. W., Chen, H., Kok, K. H., & Jin, D. Y. (2013). Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing. The Journal of general virology, 94(Pt 12), 2739–2744. https://doi.org/10.1099/vir.0.056226-0 [IF: 3.961, 2013]

Lei, T.*, Yuen, K. S.*, Xu, R., Tsao, S. W., Chen, H., Li, M., Kok, K. H., & Jin, D. Y. (2013). Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma. International journal of cancer, 133(1), 79–87. https://doi.org/10.1002/ijc.28007 [IF: 5.418, 2013] *Co-first authorship

Community/ Professional Contributions (Selected)

Journal reviewer, PLoS One

Journal reviewer, Virus Research

Journal reviewer, Emerging Microbes & Infections

Review Editor in RNA, specialty section of Frontiers in Genetics and Frontiers in Molecular Biosciences

Subject Expertise

Molecular virology

Academic Staff

+ Academic Staff

+ External Advisors

+ Administrative and Technical Staff

NEWS & EVENTS